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Updated: Jun 2, 2026

Elastomeric PGS Scaffolds in Arterial Tissue Engineering
08:35

Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Engineering porous scaffolds using gas-based techniques.

Fariba Dehghani1, Nasim Annabi

  • 1School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney 2006, Australia. Fariba.dehghani@sydney.edu.au

Current Opinion in Biotechnology
|May 7, 2011
PubMed
Summary
This summary is machine-generated.

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Scaffolds are crucial for tissue engineering, requiring controlled porosity for cell growth. This review explores gas-based methods to improve scaffold pore structure for better cell infiltration and tissue formation.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Scaffolds provide a matrix for cell seeding and attachment in tissue engineering.
  • Porous scaffolds are essential for cell proliferation, migration, differentiation, and nutrient/waste exchange.
  • Limited nutrient and oxygen diffusion (over 500μm) hinders cell migration in dense scaffolds.

Purpose of the Study:

  • To review gas-based techniques for creating porosity in three-dimensional (3D) scaffolds.
  • To highlight the importance of scaffold porosity and interconnectivity for tissue regeneration.
  • To address limitations of conventional porosity creation methods.

Main Methods:

  • Overview of gas-based techniques for scaffold fabrication.
  • Discussion of methods like electrospinning, freeze-drying, and solvent casting/salt leaching.

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Last Updated: Jun 2, 2026

Elastomeric PGS Scaffolds in Arterial Tissue Engineering
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Elastomeric PGS Scaffolds in Arterial Tissue Engineering

Published on: April 8, 2011

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
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Published on: December 8, 2015

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13:46

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

Published on: October 17, 2016

  • Focus on advancements in creating 3D porous structures.

    • Main Results:

    • Conventional methods often lack 3D structural control, pore size regulation, and pore interconnectivity.
    • Gas-based techniques offer potential improvements in scaffold architecture.
    • Optimized porosity enhances mass transfer, cell adhesion, and tissue ingrowth.

    Conclusions:

    • Effective scaffold porosity is critical for successful tissue engineering.
    • Gas-based fabrication methods show promise for overcoming limitations of traditional techniques.
    • Further development of these methods can advance regenerative medicine.