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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Human Pluripotent Stem Cell Culture on Polyvinyl Alcohol-Co-Itaconic Acid Hydrogels with Varying Stiffness Under Xeno-Free Conditions
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Fish stem cell cultures.

Ni Hong1, Zhendong Li, Yunhan Hong

  • 1Department of Biological Science, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore.

International Journal of Biological Sciences
|May 7, 2011
PubMed
Summary
This summary is machine-generated.

Medaka fish have yielded significant advancements in stem cell research, including the first haploid stem cells capable of generating whole animals and a spermatogonial stem cell line for artificial sperm production.

Keywords:
chimeragene targetinggerm cellmedakapluripotencysemi-cloningstem cell

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Aquaculture

Background:

  • Stem cell research has progressed significantly since the first embryonic stem (ES) cell cultures were established 30 years ago.
  • Fish stem cell research, initiated 20 years ago, has primarily focused on zebrafish and medaka.
  • Medaka is notable for generating ES cells, a spermatogonial stem cell line, and recently, haploid stem cells.

Purpose of the Study:

  • To review the current status and future prospects of fish stem cells in research and applications, with a focus on medaka.
  • To highlight advancements in medaka stem cell technologies, including haploid stem cells and semi-cloning.
  • To discuss the potential of fish stem cells for germline transmission and assisted reproductive technologies.

Main Methods:

  • Review of existing literature on fish stem cell derivation, characterization, and application.
  • Focus on medaka as a model organism for stem cell research.
  • Discussion of techniques such as germline transmission, gene targeting, and nuclear transfer.

Main Results:

  • Medaka has been instrumental in generating ES cells, spermatogonial stem cell lines, and haploid stem cells capable of producing whole animals.
  • Progress has been made in identifying fish pluripotency gene homologs and optimizing chimera formation.
  • Haploid ES cell nuclear transfer in medaka demonstrates the feasibility of semi-cloning for assisted reproduction.

Conclusions:

  • Medaka serves as a key model organism for advancing fish stem cell research and applications.
  • Stem cell technologies in fish, including haploid stem cells and semi-cloning, offer novel avenues for research and biotechnology.
  • Further research holds promise for germline transmission, gene targeting, and innovative reproductive strategies in fish.