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Updated: Jun 2, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
Diagnosis and management of fetal growth restriction
Jacqueline E A K Bamfo1, Anthony O Odibo
1Obstetrics and Gynecology, London Deanery, London WC1B 5DN, UK.
Insights
Fetal growth restriction (FGR) poses significant risks to newborns and adults. This review discusses diagnostic and management challenges, exploring technologies to refine care and presenting a clinical pathway for FGR pregnancies.
Area of Science:
- Perinatal medicine
- Maternal-fetal medicine
- Neonatology
Background:
- Fetal growth restriction (FGR) is a major cause of perinatal mortality and morbidity, and later-life metabolic syndrome.
- Current understanding of FGR mechanisms has advanced with ultrasound and Doppler technologies.
- A lack of consistent classification and characterization of FGR severity hinders effective management.
Purpose of the Study:
- To discuss the diagnostic and management challenges of FGR.
- To review biophysical, Doppler, biochemical, and molecular technologies for refining FGR management.
- To present a model clinical management pathway for pregnancies affected by FGR.
Main Methods:
- Literature review of diagnostic and management strategies for FGR.
- Discussion of current and emerging technologies (ultrasound, Doppler, biochemical, molecular).
- Development of a proposed clinical management pathway.
Main Results:
- Consistent classification and characterization of FGR severity are lacking.
- Timely intervention in FGR is often based on an "enigma" regarding optimal delivery timing.
- Various technologies show potential for improving FGR diagnosis and management.
Conclusions:
- Effective management of FGR relies on structured antenatal surveillance and timely intervention.
- Further research and standardized approaches are needed to address FGR challenges.
- The proposed model pathway aims to guide clinical decision-making in FGR management.
Abstract:
Fetal growth restriction (FGR) remains a leading contributor to perinatal mortality and morbidity and metabolic syndrome in later life. Recent advances in ultrasound and Doppler have elucidated several mechanisms in the evolution of the disease. However, consistent classification and characterization regarding the severity of FGR is lacking. There is no cure, and management is reliant on a structured antenatal surveillance program with timely intervention. Hitherto, the time to deliver is an enigma. In this paper, the challenges in the diagnosis and management of FGR are discussed. The biophysical profile, Doppler, biochemical and molecular technologies that may refine management are reviewed. Finally, a model pathway for the clinical management of pregnancies complicated by FGR is presented.
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