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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups.
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia, and...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Erythrocytapheresis: Do Not Forget a Useful Therapy!

Heidrun Ullrich1, Roland Fischer, Regine Grosse

  • 1Department of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|May 7, 2011
PubMed
Summary
This summary is machine-generated.

Red blood cell exchange, or erythrocytapheresis, is an effective treatment for conditions like sickle cell anemia and severe malaria, offering a safe alternative to transfusions and preventing complications without significant side effects.

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners
10:48

Isolation and Cryopreservation of Highly Viable Human Peripheral Blood Mononuclear Cells From Whole Blood: A Guide for Beginners

Published on: October 25, 2024

Area of Science:

  • Hematology
  • Therapeutic Apheresis

Background:

  • Pathologically altered erythrocytes necessitate advanced treatments.
  • Increasing global migration introduces more patients with severe malaria and sickle cell anemia.
  • Red blood cell exchange (erythrocytapheresis) is a therapeutic apheresis technique.

Purpose of the Study:

  • To evaluate the efficacy and safety of erythrocytapheresis in managing sickle cell anemia and sickle cell thalassemia.
  • To explore erythrocytapheresis as an alternative to blood transfusions, particularly for preventing iron overload.
  • To assess its role in preventing complications associated with these hematological disorders.

Main Methods:

  • Erythrocytapheresis was employed for long-term prophylaxis in sickle cell anemia and sickle cell thalassemia patients.
  • Treatment aimed to achieve specific end hematocrit levels.
  • Liver susceptometry was used to document iron balance.

Main Results:

  • Erythrocytapheresis demonstrated efficiency in treating severe malaria by reducing parasite load and restoring oxygen transport.
  • It effectively breaks the cycle of sickling and hypoxia in sickle cell disease complications like stroke and acute chest syndrome.
  • Prophylactic erythrocytapheresis prevented hemolysis in ABO-incompatible stem cell transplantations.
  • Improved iron balance was observed in treated patients.

Conclusions:

  • Erythrocytapheresis is a safe and highly efficient therapeutic option for various hematological conditions, including sickle cell disease and severe malaria.
  • It offers a valuable alternative to traditional transfusions, mitigating long-term risks like iron overload.
  • This apheresis method provides reproducible control over hematological parameters and reduces disease-specific complications.