Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of CAR T-Cell Therapy in transformed indolent Non-Hodgkin Lymphomas and de novo DLBCL: A comparative analysis from the Italian CAR T-SIE study.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Occult hepatitis B virus infection status is not associated with impaired efficacy of anti-CD19 CAR-T-cell therapy for lymphoma and shows a distinct immune toxicity profile: Results from the CART-SIE study.

HemaSphere·2026
Same author

Outcomes of patients with de novo and secondary acute myeloid leukaemia treated with front-line hypomethylating agents and venetoclax: A retrospective Italian study.

British journal of haematology·2026
Same author

Polatuzumab vedotin-containing regimens as bridge to CART: analysis from the CART-SIE study.

Blood advances·2026
Same author

Serositis as possible manifestation in MDS/AML patients with complex karyotype and TP53 mutation: case series.

Annals of hematology·2026
Same author

No lymphocytosis increase after cBTKi is a rare phenomenon except for CD49d-positive CLL mainly expressed in trisomy 12.

Blood advances·2026

Related Experiment Video

Updated: Jun 2, 2026

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)

Published on: December 24, 2015

Immune Modulation by Mesenchymal Stem Cells.

Francesco Bifari1, Veronica Lisi, Elda Mimiola

  • 1Stem Cell Research Laboratory, Section of Hematology, Department of Clinical and Experimental Medicine, University of Verona, Italy.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie
|May 7, 2011
PubMed
Summary

Mesenchymal stem cells (MSCs) are potent immune-regulating cells with therapeutic potential for immunological diseases. Careful consideration of MSCs

More Related Videos

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Related Experiment Videos

Last Updated: Jun 2, 2026

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells (MSCs)

Published on: December 24, 2015

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

Area of Science:

  • Immunology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Mesenchymal stem cells (MSCs) possess immunomodulatory properties, acting as regulatory cells.
  • They influence key immune effectors and functions, similar to dendritic cells.
  • MSCs show promise for treating various human immunological diseases.

Purpose of the Study:

  • To highlight the regulatory capacity of MSCs in immune responses.
  • To discuss the potential of MSCs in treating immunological disorders.
  • To emphasize the importance of optimizing MSC therapy parameters.

Main Methods:

  • Review of existing literature on MSC immunomodulation.
  • Analysis of MSCs' role as immune effectors and regulators.
  • Consideration of factors influencing MSC therapeutic outcomes.

Main Results:

  • MSCs act as powerful immune-regulatory cells, influencing major immune effectors.
  • Their stromal progeny also exhibit significant immunomodulatory functions.
  • MSC-based therapies offer potential for treating human immunological diseases.

Conclusions:

  • Optimizing MSC tissue origin, dose, administration, and schedule is crucial.
  • Careful management of potential side effects, like tumor enhancement, is necessary.
  • Maximizing benefits of MSC-dependent immune regulation requires risk-benefit assessment.