Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 2, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
07:48

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis

Published on: January 7, 2019

PET Imaging of Integrin αVβ3 Expression.

Ambros J Beer1, Horst Kessler, Hans-Jürgen Wester

  • 11. Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Theranostics
|May 7, 2011
PubMed
Summary

Positron emission tomography (PET) imaging of integrin αvβ3 shows promise as a biomarker for tumor angiogenesis and metastasis. Various radiotracers are being developed, with ongoing clinical trials to confirm their value.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating Metabolic, Perfusion, and Microstructural Parameters for Quantitative Neuroimaging in Rare Neurodegenerative Diseases: A Hybrid PET/MRI Approach.

Diagnostics (Basel, Switzerland)·2026
Same author

ASO Visual Abstract: Sentinel Node Biopsy in the Neck Management of cN0 Sinonasal Squamous Cell Carcinoma-A Multicenter Pilot Trial on Safety and Feasibility.

Annals of surgical oncology·2026
Same author

Assessment of active fibrotic remodeling in patients with idiopathic pulmonary fibrosis (IPF)/progressive pulmonary fibrosis (PPF) using dual-time-point [<sup>68</sup>Ga]Ga-FAPI-46-PET/CT.

European journal of radiology·2026
Same author

Sentinel Node Biopsy in the Neck Management of cN0 Sinonasal Squamous Cell Carcinoma: A Multicenter Pilot Trial on Safety and Feasibility.

Annals of surgical oncology·2026
Same author

Detection of inflammation-related blood-brain barrier dysfunction using PET and MR imaging: a pilot study.

Scientific reports·2026
Same author

Advanced neuroimaging assessment of neurodegenerative dementia syndromes: A framework for comprehensive multimodal FDG-PET, MR-perfusion, and MR-diffusion analysis.

NeuroImage. Clinical·2026

Area of Science:

  • Oncology
  • Radiochemistry
  • Molecular Imaging

Background:

  • Integrin αvβ3 is crucial in tumor metastasis and angiogenesis.
  • PET imaging offers in-vivo assessment of biological processes.
  • Targeting integrin αvβ3 could provide insights into tumor behavior.

Purpose of the Study:

  • To summarize strategies for PET imaging of integrin αvβ3.
  • To review preclinical and clinical findings.
  • To discuss the potential clinical utility of this imaging biomarker.

Main Methods:

  • Review of various radiolabeled RGD peptides (monomeric and multimeric).
  • Evaluation of nanoparticle-based PET imaging agents.
  • Analysis of preclinical tumor models and clinical study results.
Keywords:
PETangiogenesisintegrin αvβ3metastasismolecular imaging

More Related Videos

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
07:20

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor

Published on: April 25, 2019

Related Experiment Videos

Last Updated: Jun 2, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
07:48

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis

Published on: January 7, 2019

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
07:20

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor

Published on: April 25, 2019

Main Results:

  • Multiple radiotracer strategies for integrin αvβ3 PET imaging have been successfully developed.
  • Preclinical data strongly support the potential of this approach.
  • Emerging clinical data are becoming available and are discussed.

Conclusions:

  • PET imaging of integrin αvβ3 is a rapidly advancing field.
  • Significant progress has been made in developing PET tracers.
  • Further large-scale clinical trials are needed to establish definitive clinical value.