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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Activation of Integrins01:15

Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding events provide an effective stimulus.

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Related Experiment Video

Updated: Jun 2, 2026

A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs
04:15

A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs

Published on: February 2, 2024

Integrin targeted therapeutics.

Melissa Millard1, Srinivas Odde, Nouri Neamati

  • 1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, PSC304 1985 Zonal Avenue, Los Angeles, CA 90089.

Theranostics
|May 7, 2011
PubMed
Summary

Integrin drugs show promise for treating diseases by targeting these key cell receptors. This review evaluates current and developing therapies for various conditions.

Keywords:
Crohn's DiseaseIntegrin-targeted therapeuticsMultiple Sclerosisabciximababegrinacute coronary syndromesage related macular degenerationangiogenesiscancercilengitideeptifibatideintegrin-targeted peptidesintegrin-targeted small moleculesintegrin-targeted therapeutic antibodiesnatalizumabosteoporosistirofiban

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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

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A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs
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Area of Science:

  • Cell biology
  • Pharmacology
  • Biochemistry

Background:

  • Integrins are transmembrane receptors crucial for cell adhesion, mechanosensing, and signal transduction.
  • Dysfunction of integrins is implicated in numerous disease states, highlighting their pathological significance.

Purpose of the Study:

  • To review and evaluate drugs and compounds that target integrins.
  • To examine the disease states in which integrin-targeted therapies are applied.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of approved and investigational integrin-targeting drugs.
  • Evaluation of therapeutic efficacy in various disease contexts.

Main Results:

  • Several integrin-targeted drugs are approved for clinical use.
  • Numerous other compounds are in clinical trials or preclinical development.
  • These therapies show promise for treating a range of diseases.

Conclusions:

  • Pharmacological inhibition of integrins is a significant therapeutic strategy.
  • Ongoing research and development continue to expand the potential of integrin-targeted treatments.
  • Integrin-targeted drugs offer a promising avenue for disease prevention and treatment.