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[Pancreatic polypeptide (author's transl)].

W Gepts, J de Mey

    Diabete & Metabolisme
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Pancreatic polypeptide (PP) is a hormone found in the pancreas. Research reviews its ill-defined role, species-specific actions, and association with diabetes and obesity.

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    Area of Science:

    • Endocrinology
    • Gastroenterology

    Context:

    • Pancreatic Polypeptide (PP) was first identified in birds and later in mammals.
    • PP is present in the islets of many animal species and assayable in plasma.
    • Its physiological role and pharmacological properties remain largely undefined and appear species-specific.

    Purpose:

    • To review recent research on Pancreatic Polypeptide (PP).
    • To discuss the clinical significance of PP levels and PP-cell morphology.

    Summary:

    • High circulating PP levels are observed in diabetics and patients with islet cell tumors.
    • PP-cell hyperplasia, particularly in chronic insulin-dependent diabetics, suggests atypical islet regeneration.
    • A deficiency in PP may be linked to obesity, though no definitive clinical syndrome of PP hypersecretion is identified.

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    Impact:

    • Highlights the need for further research into PP's physiological functions and clinical implications.
    • Suggests PP-cell hyperplasia as a potential indicator of pancreatic islet regeneration in specific pathological conditions.
    • Provides a review of current knowledge on PP, relevant for endocrinologists and researchers in metabolic diseases.