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Transient deflection response in microcantilever array integrated with polydimethylsiloxane (PDMS) microfluidics.

Ryan R Anderson1, Weisheng Hu, Jong Wook Noh

  • 1Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA.

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This study integrates silicon microcantilevers with microfluidics to detect analytes. The nanomechanical sensor shows high sensitivity to non-specific binding and pH changes, enabling precise surface stress measurements.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Analytical Chemistry

Background:

  • Nanomechanical sensors offer high sensitivity for detecting molecular interactions.
  • Microfluidic systems enable precise control of fluid flow and analyte delivery.
  • Integrating these technologies allows for advanced biosensing applications.

Purpose of the Study:

  • To characterize a novel nanomechanical sensor array integrated with polydimethylsiloxane (PDMS) microfluidics.
  • To investigate the sensor's response to non-specific binding and pH variations.
  • To validate sensor performance using a high-sensitivity photonic transduction method.

Main Methods:

  • Fabrication of a 16-silicon microcantilever array integrated with PDMS microfluidics.
  • Utilizing a transient differential analyte concentration within the microfluidic channel.
  • Employing a high-sensitivity in-plane photonic transduction method for simultaneous readout.
  • Characterizing sensor response to bovine serum albumin (BSA) adsorption and buffer solutions with varying pH.

Main Results:

  • Observed maximum transient microcantilever deflection of -1.6 nm for BSA non-specific binding, corresponding to -0.23 mN m(-1) differential surface stress.
  • Measured deflections of 20-100 nm (2-14 mN m(-1) differential surface stress) for pH changes.
  • Determined average temporal width (FWHM) of transient response: 5.3 s for BSA and 0.74 s for pH changes at 5 μL min(-1) flow rate.

Conclusions:

  • The integrated nanomechanical sensor array demonstrates excellent sensitivity and agreement with theoretical models.
  • The system effectively characterizes surface stress changes due to molecular binding and environmental variations (pH).
  • This technology holds promise for sensitive and precise real-time analysis in microfluidic systems.