Survival data for 299 patients with primary cutaneous lymphomas: a monocentre study

Area of Science:

• Dermatology
• Oncology
• Hematology

Background:

• Primary cutaneous lymphomas (PCL) are a heterogeneous group of non-Hodgkin lymphomas.
• Accurate classification is crucial for prognosis and treatment of PCL.

Purpose of the Study:

• To retrospectively assess the validity of the 2005 World Health Organization-European Organisation for Research and Treatment of Cancer (WHO-EORTC) classification for PCL.
• To evaluate the reliability of the WHO-EORTC classification in a large, single-center German cohort.

Main Methods:

• Retrospective monocentric study of 312 patients with PCL diagnosed between 1980 and 2005.
• Analysis of histological and clinical data for classification and survival assessment.
• Inclusion criteria required sufficient clinical information and paraffin material for detailed classification in 299 patients.

Main Results:

• T-cell phenotype (63%) was more common than B-cell phenotype (37%).
• Most frequent PCL entities included mycosis fungoides (30.9%), primary cutaneous follicle center lymphomas (16.9%), and lymphomatoid papulosis (15.9%).
• Five-year disease-specific survival rates varied by PCL type, with lymphomatoid papulosis and primary cutaneous marginal zone lymphoma showing 100% survival.

Conclusions:

• The study findings align with WHO-EORTC data, supporting its reliability.
• The 2005 WHO-EORTC classification and staging system are validated as reliable tools for primary cutaneous lymphomas.
• This provides further evidence for the robustness of the WHO-EORTC classification in clinical practice.