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Dextromethorphan sites, sigma receptors, and the psychotomimetic effects of sigma opiates
J M Musacchio1, M Klein, P D Canoll
1Department of Pharmacology, N.Y.U. School of Medicine, NY 10016.
Progress in Clinical and Biological Research
|January 1, 1990
Abstract:
A review of the literature shows that the dysphoric and psychotomimetic side effects of opiate agonist-antagonist reside in the opiate levorotatory isomer. Thus, the current definition of the sigma receptor cannot explain the psychotomimetic effects of sigma opiates.