Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mucosal enzyme patterns in gastric epithelial disease.

P A Mooney, J M Walters, M P Little

    Digestion
    |January 1, 1978
    PubMed
    Summary

    Changes in gastric acid secretion enzymes, specifically ATPases, correlate with histological damage in stomach biopsies. These enzyme alterations serve as sensitive indicators of gastric mucosal disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Non-cancer effects of radiation exposure: Cataracts, diseases of the circulatory system, and beyond.

    Annals of the ICRP·2026
    Same author

    Machine learning techniques for the prediction of indoor gamma-ray dose rates - Strengths, weaknesses and implications for epidemiology.

    Journal of environmental radioactivity·2024
    Same author

    Change in salt intake affects blood pressure of chimpanzees implications for human populations. Circulation 116: 1563-1568, 2007.

    Clinical journal of the American Society of Nephrology : CJASN·2023
    Same author

    The Evidence for Excess Risk of Cancer and Non-Cancer Disease at Low Doses and Dose Rates.

    Radiation research·2022
    Same author

    THYROID SCREENING AND RELIABILITY OF RADIATION THYROID DOSES FOR THE BELARUSIAN IN UTERO COHORT.

    Problemy radiatsiinoi medytsyny ta radiobiolohii·2021
    Same author

    Modelling the bimodal distribution of indoor gamma-ray dose-rates in Great Britain.

    Radiation and environmental biophysics·2018

    Area of Science:

    • Gastroenterology
    • Molecular Biology
    • Pathology

    Background:

    • Gastric acid secretion is regulated by various enzymes.
    • Histological changes in gastric mucosa indicate disease.
    • Understanding enzyme activity in relation to histology is crucial.

    Purpose of the Study:

    • To investigate the correlation between gastric acid secretion enzymes (ATPases) and histological changes in gastric biopsies.
    • To assess the diagnostic potential of ATPase activity in gastric mucosal diseases.

    Main Methods:

    • Analysis of Mg-, NaK-, K-, and HCO3-stimulated ATPase activities in gastric biopsies.
    • Histopathological examination of gastric biopsies to assess gastritis, intestinal metaplasia, and atrophic gastritis.
    • Measurement of alkaline phosphatase activity for comparison.

    Main Results:

    • Increased Mg- and NaK-stimulated ATPase activities were observed in pylorus and antrum with moderate/severe gastritis.
    • Elevated NaK ATPase and decreased HCO3 ATPase levels were found in incisural, body, and fundic mucosa with intestinal metaplasia and atrophic gastritis.
    • No K+ ATPase activity was detected in normal gastric mucosa. Alkaline phosphatase activity showed no variation with histological changes.

    Conclusions:

    • ATPase enzyme systems are sensitive indicators of gastric mucosal disease.
    • Specific ATPase alterations correlate with distinct histological findings in the stomach.
    • This study highlights the utility of ATPase activity in diagnosing gastric pathology.

    Related Experiment Videos