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Updated: Jun 2, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Disseminated lupus vulgaris.

Taru Garg¹, Ramchander, Rashmi Shrihar

¹Department of Dermatology, Venereology, and Leprosy, Lady Hardinge Medical College, New Deihi, India. drtarugarg@rediffmail.com

|May 10, 2011

Summary

This case study highlights lupus vulgaris, a chronic skin tuberculosis, co-occurring with pulmonary tuberculosis in a 28-year-old woman. Diagnosis involved clinical presentation, imaging, and histopathology, emphasizing the importance of considering tuberculosis in diverse skin manifestations.

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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

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Published on: June 10, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Area of Science:

Dermatology
Infectious Diseases
Public Health

Background:

Lupus vulgaris is a chronic cutaneous form of tuberculosis (TB) that can present with varied clinical manifestations.
Co-infection with pulmonary TB and lupus vulgaris requires careful diagnostic consideration and management.

Purpose of the Study:

To present a case of lupus vulgaris with disseminated lesions and co-existing pulmonary tuberculosis.
To discuss the diagnostic challenges and therapeutic implications of this dual infection.

Main Methods:

Clinical case presentation with detailed patient history and physical examination.
Diagnostic workup included imaging (chest X-ray), laboratory tests (hemogram, ESR), Mantoux test, and histopathology of skin lesions.
Cultures and human immunodeficiency virus (HIV) serology were also performed.

Main Results:

The patient presented with chronic facial and ear lesions, a history of axillary lymphadenopathy, and systemic symptoms suggestive of active TB.
Histopathology revealed epithelioid cell granulomas consistent with tuberculosis, and chest X-ray showed fibrotic changes indicative of pulmonary TB.
Mantoux test was strongly positive, while acid-fast bacilli stains and cultures from skin lesions were negative.

Conclusions:

Lupus vulgaris can present with diverse skin lesions and may coexist with pulmonary tuberculosis.
Early diagnosis and appropriate anti-tuberculosis treatment are crucial for managing co-infected patients.
This case underscores the importance of a high index of suspicion for TB in patients with chronic, atypical skin conditions.