Lipoprotein (a) level in pre-eclampsia patients

This study was carried in BSMMU from July 2001 to June 2003. During the study period, 60 pregnant women were studied. Thirty patients were preeclamptic and thirty were normal healthy pregnant women served as control. Serum lipoprotein(a) was found significantly higher in preeclamptic women 56.63 +/- 22.6 mg/dl and found within limit in normal healthy pregnant women, 12.89 +/- 4.59 mg/dl. Result is statistically highly significant (P < 0.001). Mean systolic blood pressure was 163.33 +/- 29.63 mmHg and 117.00 +/- 11.19 mmHg in case and control and Diastolic Blood Pressure was 108.53 +/- 14.54 mmHg and 76.00 +/- 6.87 mmHg respectively in case and control group. Result was highly significant as P < 0.001. The mean (+/- SD) serum lipoprotein(a) concentration in normal pregnancies and preeclampsia were found to be 12.91 +/- 4.94 and 56.65 +/- 22.62. Moderate proteinuria was found in 77.5% and severe proteinuria in 22.2% cases of preeclampsia respectively. Regardless of mechanism and pathophysiology of preeclampsia, we found high serum level of lipoprotein (a) in preeclampsia patients. These high levels of lipoprotein (a) significantly correlated with blood pressure and proteinuria.