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Electrospray Ionization (ESI) Mass Spectrometry

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...

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Electrospray as a tool for drug micro- and nanoparticle patterning.

Elke Scholten¹, Himanshu Dhamankar, Lev Bromberg

¹Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|May 10, 2011

Summary

Carbamazepine (CBZ) microparticles were electrosprayed into various sizes and shapes. Higher CBZ concentrations resulted in larger particles, influenced by solvent evaporation and solidification dynamics.

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Area of Science:

Pharmaceutical Technology
Materials Science
Chemical Engineering

Background:

Carbamazepine (CBZ) is an important antiepileptic drug.
Controlling microparticle size and shape is crucial for drug delivery.
Electrospraying offers a versatile method for microparticle fabrication.

Purpose of the Study:

To investigate the formation of Carbamazepine (CBZ) microparticles with varying sizes and shapes.
To understand the influence of CBZ concentration on particle characteristics.
To correlate particle morphology with electrospraying process parameters.

Main Methods:

Electrospraying of Carbamazepine (CBZ) solutions at different concentrations.
Characterization of microparticle size and shape using microscopy.
Analysis of particle formation based on jetting, droplet breakup, and solidification principles.

Main Results:

Microparticles exhibited diverse shapes including spheres, q-tips, elongated spheres, and tear-shapes.
Average particle size increased with increasing CBZ concentration.
Particle morphology was dependent on CBZ concentration and influenced by Rayleigh instability.

Conclusions:

Electrospraying allows tunable fabrication of Carbamazepine (CBZ) microparticles.
CBZ concentration is a key parameter controlling microparticle size and shape.
Understanding solidification dynamics is essential for predicting final particle characteristics.