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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 2, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Quantitative, high-resolution proteomics for data-driven systems biology.

Jürgen Cox1, Matthias Mann

  • 1Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried D-82152, Germany. cox@biochem.mpg.de

Annual Review of Biochemistry
|May 10, 2011
PubMed
Summary
This summary is machine-generated.

Mass spectrometry (MS)-based proteomics globally measures proteins for systems biology. This quantitative proteomic data aids in understanding protein structure, interactions, and cellular localization across various biological states.

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Last Updated: Jun 2, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Area of Science:

  • Proteomics
  • Systems Biology
  • Molecular Biology

Background:

  • Systems biology necessitates comprehensive molecular data.
  • Mass spectrometry (MS)-based proteomics is a key technology for global protein measurement.
  • Peptide intensity data from MS is fundamental for quantitative proteomics.

Purpose of the Study:

  • To describe the principles of MS-based proteomics analysis.
  • To highlight the unique contributions of proteomics to systems biology.
  • To address opportunities and challenges in utilizing large-scale proteomics data.

Main Methods:

  • Liquid chromatography (LC) coupled to high-resolution tandem mass spectrometry (MS/MS).
  • Large-scale identification and quantification of peptides.
  • Analysis of peptide intensity data for protein quantification.

Main Results:

  • Proteomics enables large-scale quantification of proteins across different states.
  • It facilitates determination of protein primary structure, including post-translational modifications.
  • Proteomics aids in organelle localization and protein interaction studies.

Conclusions:

  • MS-based proteomics is a powerful tool for systems biology research.
  • The quantitative proteomic data offers unique insights into biological systems.
  • Further exploration of large-scale proteomics data presents significant opportunities for systems biology.