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Related Experiment Video

Updated: Jun 2, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

T2*-based fiber orientation mapping.

Jongho Lee¹, Peter van Gelderen², Li-Wei Kuo²

¹Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA; Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

|May 10, 2011

Summary

This summary is machine-generated.

High-field MRI reveals white matter T(2)*-weighted signal changes related to fiber orientation. This orientation dependency, explained by anisotropic magnetic susceptibility, could be used for generating brain fiber maps.

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Last Updated: Jun 2, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

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Published on: May 23, 2017

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Published on: January 8, 2013

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

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Published on: December 12, 2012

Area of Science:

Neuroimaging
Magnetic Resonance Imaging (MRI)
Biophysics

Background:

High-field MRI (7 Tesla) studies have observed orientation-dependent T(2)*-weighted MRI signals in white matter.
This signal variation is linked to the angle (θ) of white matter fiber bundles relative to the main magnetic field (B(0)).

Purpose of the Study:

To quantitatively investigate the characteristics of the orientation dependency of T(2)*-weighted MRI signals in white matter.
To explore the potential of using this orientation dependency for generating fiber orientation maps.

Main Methods:

Utilized ex-vivo human brain specimens for high-field (7 T) MRI.
Measured T(2)*-weighted MRI signal across a wide range of fiber orientation angles (θ).
Analyzed the relationship between R(2)* (1/T(2)*) and θ.

Main Results:

Confirmed the previously suggested variation of R(2)* with fiber orientation θ.
The dependency was characterized by a combination of sin2θ and sin4θ functions.
Observed significant modulation amplitudes (ΔR(2)* up to 6.44±0.15 Hz) in major white matter tracts like the corpus callosum.
This dependency is explained by anisotropic, sub-voxel scale magnetic field variations due to magnetic susceptibility.

Conclusions:

The orientation dependence of R(2)* in white matter is quantitatively characterized at 7 T.
This phenomenon can be attributed to anisotropic magnetic susceptibility at the sub-voxel level.
The study demonstrates the feasibility of generating fiber orientation maps using R(2)* data, highlighting a potential new application in neuroimaging.