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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
Published on: May 30, 2016
Endothelialized biomaterials for tissue engineering applications in vivo
Omar F Khan1, Michael V Sefton
1Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada.
Trends in Biotechnology
|May 10, 2011
Summary
Engineering functional vasculature requires quiescent endothelial cells (ECs) on biomaterials. Optimizing implant performance depends on EC origin, surface chemistry, and hemodynamics for nutrient supply in tissue rebuilding.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Vascular Biology
Background:
- Tissue regeneration necessitates functional vasculature for nutrient delivery.
- Endothelial cells (ECs) form the inner lining of blood vessels, crucial for non-thrombogenic blood contact.
- Biomaterials, including natural and synthetic polymers, are used for vascular grafts and tissue-engineered constructs.
Purpose of the Study:
- To review the in vivo application of endothelialized biomaterials.
- To discuss critical factors for engineering functional vasculature.
- To highlight considerations for optimizing implant performance.
Main Methods:
- Literature review of recent in vivo studies on endothelialized biomaterials.
- Analysis of factors influencing endothelial cell function: origin, biomaterial surface chemistry, and hemodynamics.
Main Results:
- Endothelialized biomaterials are increasingly used in vivo for tissue rebuilding.
- EC origin, biomaterial surface chemistry, and hemodynamic forces significantly impact EC function.
- Optimizing these factors is essential for successful vascularization.
Conclusions:
- Successful tissue engineering relies on creating quiescent, non-thrombogenic endothelial surfaces.
- Careful consideration of EC origin, biomaterial properties, and blood flow is vital for implant success.
- Further research into engineering functional vasculature is needed.
