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Updated: Jun 2, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Hypertension: how does management change with aging?

Milta O Little¹

¹Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Room M238, St Louis, MO 63139, USA. mlittle6@slu.edu

The Medical Clinics of North America

|May 10, 2011

Summary

For older adults, managing hypertension is crucial for reducing cardiovascular risks. The best approach involves age-adjusted blood pressure goals and initiating treatment with thiazide diuretics or ACE inhibitors when systolic pressure exceeds 160/90 mmHg.

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Last Updated: Jun 2, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

Gerontology
Cardiology
Internal Medicine

Background:

Hypertension in individuals over 60 is a major contributor to cardiovascular disease, morbidity, and mortality.
Isolated systolic hypertension and pulse pressure are key indicators, potentially more significant than diastolic hypertension.
Orthostatic hypotension and very low blood pressure are linked to increased mortality and require regular monitoring.

Purpose of the Study:

To review the evidence-based management of hypertension in older adults.
To define optimal blood pressure targets and initial therapeutic strategies for this demographic.

Main Methods:

Review of current best evidence and clinical guidelines.
Analysis of risk factors, including isolated systolic hypertension and orthostatic hypotension.
Evaluation of therapeutic interventions and their impact on outcomes.

Main Results:

Elevated blood pressure, specifically greater than 160/90 mmHg, necessitates treatment for improved outcomes.
Age-adjusted blood pressure goals are recommended for older populations.
Thiazide diuretics are identified as the first-line therapy, with angiotensin-converting enzyme inhibitors as a viable alternative.

Conclusions:

Tailoring hypertension management to age is essential for older adults.
Early intervention with appropriate pharmacotherapy, such as thiazide diuretics or ACE inhibitors, can mitigate cardiovascular risks.
Regular assessment for hypotension is critical in elderly patients.