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Allergic Reactions

Allergic Reactions

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Updated: Jun 2, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

[House dust mites allergens].

J-C Bessot¹, G Pauli

¹Ariale, bâtiment ancienne ophtalmologie, hôpital Civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.

Revue Des Maladies Respiratoires

|May 10, 2011

Summary

This summary is machine-generated.

Molecular understanding of house dust mite allergens has advanced significantly, improving allergy diagnosis and enabling new immunotherapy strategies. This knowledge helps explain cross-reactions and guides the selection of diagnostic and therapeutic allergen molecules.

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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

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Last Updated: Jun 2, 2026

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

Immunology
Molecular Biology
Allergology

Context:

House dust mite allergens are potent sensitizers, causing significant allergic reactions.
Over 22 mite allergens have been identified, with Groups 1 and 2 being major IgE binders.

Purpose:

To review the molecular knowledge of house dust mite allergens.
To discuss the implications for understanding allergic sensitization and developing new therapies.

Summary:

Major allergens like Der p 1 (cysteine protease) and Der p 2 (structural homology to MD-2) have known structures and functions.
Molecular epidemiology aids in selecting effective diagnostic and therapeutic allergen molecules.
Understanding allergen structures facilitates interpretation of cross-reactivity between different mite families.

Impact:

Improved diagnosis of allergic sensitization through molecular epidemiology.
Development of novel immunotherapy approaches using hypoallergenic allergen variants.
Better explanation for multisensitization in allergic individuals.