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Related Concept Videos

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Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
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Human Genetics

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Related Experiment Video

Updated: Jun 2, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

The 5-HTTLPR polymorphism, impulsivity and suicide behavior in euthymic bipolar patients.

Leandro Fernandes Malloy-Diniz1, Fernando Silva Neves, Paulo Henrique Paiva de Moraes

  • 1Departamento de Psicologia da Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Faculdade de Filosofia e Ciências Humanas, Sala 4010, Belo Horizonte, Minas Gerais, Brazil. malloy.diniz@gmail.com

Journal of Affective Disorders
|May 10, 2011
PubMed
Summary

Individuals with bipolar disorder (BD) exhibit higher impulsivity, particularly cognitive impulsivity, which is linked to suicide attempts. The serotonin transporter gene polymorphism (5-HTTLPR) did not show an association with these impulsive behaviors in this study.

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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
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Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

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Last Updated: Jun 2, 2026

Developing a Rat Model for Bipolar Disorder
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Published on: May 2, 2025

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Suicide behavior is prevalent in Bipolar Disorder (BD) and linked to impulsivity and serotonergic function.
  • The serotonin transporter gene polymorphism (5-HTTLPR) may play a role in these associations.
  • Impulsivity components require further investigation in BD, especially concerning suicide attempts.

Purpose of the Study:

  • To compare impulsivity components in BD patients with and without a history of suicide attempts versus healthy controls.
  • To investigate the association between 5-HTTLPR genotypes and cognitive impulsivity in BD.
  • To explore the relationship between impulsivity, suicide behavior, and genetic factors in BD.

Main Methods:

  • Assessed 95 euthymic bipolar patients (sub-grouped by suicide attempt history) and 94 healthy controls.
  • Utilized laboratory assessments for impulsivity, including the Continuous Performance Test and Iowa Gambling Test.
  • Performed genotyping for the 5-HTTLPR polymorphism in all participants.

Main Results:

  • Bipolar patients demonstrated significantly higher impulsivity across all studied dimensions compared to healthy controls.
  • Bipolar patients with a history of suicide attempts exhibited greater cognitive impulsivity than those without and healthy controls.
  • No significant association was found between 5-HTTLPR genotypes and the neuropsychological measures of impulsive behavior.

Conclusions:

  • A history of suicide attempts in bipolar disorder appears associated with cognitive impulsivity, independent of other studied variables and 5-HTTLPR genotype.
  • Limitations include a small sample size and uncontrolled medication status.
  • Further research with larger, controlled samples is necessary to confirm these findings.