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Related Experiment Video

Updated: Jun 2, 2026

Laser-inflicted Injury of Zebrafish Embryonic Skeletal Muscle
07:13

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Published on: January 30, 2013

Laser-induced thrombosis in zebrafish.

Pudur Jagadeeswaran1, Maira Carrillo, Uvaraj P Radhakrishnan

  • 1Department of Biological Sciences, University of North Texas, Denton, Texas, USA.

Methods in Cell Biology
|May 10, 2011
PubMed
Summary

Researchers developed a novel laser-induced thrombosis method for genetic studies of hemostasis. This global screening tool assays all hemostatic components, enabling comprehensive analysis in zebrafish.

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Area of Science:

  • * Genetics
  • * Vascular Biology
  • * Biomedical Engineering

Background:

  • * Hemostasis is a critical defense mechanism in vertebrates to stop bleeding after vascular injury.
  • * While biochemical factors of hemostasis are known, classical genetic approaches have been limited.
  • * Zebrafish offer a promising model for genetic studies of hemostasis.

Purpose of the Study:

  • * To establish a global screening method for genetic studies of hemostasis.
  • * To develop a method capable of assaying all hemostatic components (plasma, platelets, endothelium).
  • * To introduce zebrafish as a model organism for hemostasis genetics.

Main Methods:

  • * Development of a global laser-induced thrombosis method.
  • * Assay of hemostatic components including plasma, platelets, and endothelial factors.

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Last Updated: Jun 2, 2026

Laser-inflicted Injury of Zebrafish Embryonic Skeletal Muscle
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Published on: January 30, 2013

Mechanical Vessel Injury in Zebrafish Embryos
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  • * Detailed protocol provided for laboratory implementation.

    • Main Results:

    • * A functional global screening method for hemostasis genetics was successfully developed.
    • * The laser-induced thrombosis method can comprehensively assess various hemostatic factors.
    • * Zebrafish are validated as a suitable model for genetic hemostasis research.

    Conclusions:

    • * The laser-induced thrombosis method provides a powerful tool for genetic screening of hemostasis.
    • * This approach enables a comprehensive understanding of the genetic regulation of hemostasis.
    • * The study facilitates future genetic research into bleeding disorders and thrombosis.