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Updated: Jun 2, 2026

Rapid and Specific Immunomagnetic Isolation of Mouse Primary Oligodendrocytes
Published on: May 21, 2018
Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein
Eitan M Akirav1, Yan Xu, Nancy H Ruddle
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Abstract:
Thymic B cells represent a numerically minor cell population located primarily at the cortico-medullary junction. Their biological role is unclear. B cell-deficient microMT mice exhibited reduced medullary thymic epithelial cell (mTEC) numbers and reduced MOG and insulin mRNA expression. Lymphotoxin produced by B cells was critical for normal tissue restricted antigen (TRA) expression, suggesting that B cells regulate self-antigens through their production of LT. These results reveal an unexpected role of B cells in mTEC maintenance and expression of TRAs through their production of LT.
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