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Related Experiment Video

Updated: Jun 2, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Perifoveal exudative vascular anomalous complex.

G Querques¹, D Kuhn, N Massamba

¹Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, université de Paris-XII, 40, avenue de Verdun, 94000 Créteil, France. giuseppe.querques@hotmail.it

Journal Francais D'Ophtalmologie

|May 10, 2011

Summary

This summary is machine-generated.

Isolated perifoveal exudative vascular anomalous complex (PEVAC) presents unique angiographic and OCT features. This condition may stem from endothelial cell degeneration, explaining resistance to anti-VEGF therapies.

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Area of Science:

Ophthalmology
Retinal Vascular Diseases
Medical Imaging

Background:

Perifoveal exudative vascular anomalous complex (PEVAC) is a rare clinical entity.
Understanding its distinct features is crucial for accurate diagnosis and management.

Observation:

Two patients presented with unilateral blurred vision and isolated perifoveal aneurismal changes.
Fundus examination revealed hemorrhages, exudation, and hard exudates.
Fluorescein angiography (FA) and indocyanine green angiography (ICGA) showed no other vascular abnormalities.

Findings:

Optical coherence tomography (OCT) demonstrated a hyperreflective lesion with surrounding intraretinal cystic spaces.
One patient showed no improvement after three monthly intravitreal ranibizumab injections.

Implications:

PEVAC may arise from progressive retinal endothelial cell degeneration, independent of ischemia or inflammation.
This etiology could account for the observed unresponsiveness to anti-vascular endothelial growth factor (anti-VEGF) treatments.
Further research into PEVAC pathogenesis is warranted to explore alternative therapeutic strategies.