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The relationship of plasminogen activators and oncogenes to tumour invasion
J S Gelister1, P B Boulos, P J Gaffney
1Department of Surgery, Faculty of Clinical Sciences, University College London, Rayne Institute.
Abstract:
Accruing evidence suggests an association between increased activity of plasminogen activators and transformed cells, and urokinase activity with tumour aggressiveness. The PIP2 pathway seems to provide a link between oncogene-associated transformation, cellular proliferation, plasminogen-activator expression and tumour invasion and metastasis.