Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Secondary Spinal Cord Injury llI: Pathophysiology

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

Spinal Cord Injury ll: Pathophysiology

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In reply to Liu.

Anaesthesia and intensive care·2018

Same author

Perioperative assessment of older surgical patients using a frailty index-feasibility and association with adverse post-operative outcomes.

Anaesthesia and intensive care·2017

Same author

Hematological profile of HIV patients in relation to immune status - a hospital-based cohort from Varanasi, North India.

Turkish journal of haematology : official journal of Turkish Society of Haematology·2016

Same author

Development of trochlear motor neurons, superior oblique muscle, and neuromuscular junctions following prevention of cell death by myasthenia gravis immunoglobulin.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2014

Same author

Restoration of denervated skeletal muscle transplants after reinnervation in rats.

Restorative neurology and neuroscience·2011

Same author

[Not Available].

Canadian family physician Medecin de famille canadien·2010

Search research articles

Related Experiment Video

Updated: Jun 2, 2026

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

Chronic spinal cord transection does not affect peripheral nerve regeneration.

A K Gulati¹, T R Swift, R L McBride

¹Department of Anatomy Medical College of Georgia, Augusta, GA 30912 (U.S.A.).

Restorative Neurology and Neuroscience

|May 10, 2011

Summary

This summary is machine-generated.

Peripheral nerve regeneration remains possible after spinal cord injury. Studies show peroneal nerve regeneration and muscle reinnervation in rats following a T9 spinal cord transection and nerve crush injury.

More Related Videos

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Related Experiment Videos

Last Updated: Jun 2, 2026

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord

Published on: November 20, 2009

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Area of Science:

Neuroscience
Regenerative Medicine
Spinal Cord Injury Research

Background:

Spinal cord transection leads to progressive motor neuron and hind limb muscle changes.
Understanding the capacity for peripheral nerve repair post-spinal cord injury is crucial.

Purpose of the Study:

To investigate peroneal nerve regeneration in rats 25 weeks after a T9 spinal cord transection.
To determine if peripheral nerve regeneration is impaired by spinal cord injury.

Main Methods:

Induction of T9 spinal cord transection in adult rats.
Application of a crush injury to the peroneal nerve distal to the spinal cord lesion.
Assessment of nerve regeneration and muscle reinnervation at 25 weeks post-injury.

Main Results:

Successful regeneration of the peroneal nerve was observed in rats with a prior spinal cord transection.
Evidence of successful reinnervation of the target hind limb muscle was found.
The peripheral nerve demonstrated the capacity to regenerate despite the presence of spinal cord injury.

Conclusions:

The intrinsic ability of peripheral nerves to regenerate is preserved even after significant spinal cord injury.
These findings suggest potential therapeutic avenues for enhancing nerve repair in patients with spinal cord injuries.
Peripheral nerve regeneration capacity is not abolished by spinal cord transection.