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Related Experiment Video

Updated: Jun 2, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Published on: May 31, 2016

Osteo-progenitors in vascular calcification: a circulating cell theory.

Shripad Nagesh Pal¹, Jonathan Golledge

¹Vascular Biology Unit, Department of Surgery, School of Medicine and Dentistry, James Cook University, Townsville, QLD, Australia.

Journal of Atherosclerosis and Thrombosis

|May 10, 2011

Summary

Vascular calcification, a risk factor for cardiovascular events, may involve bone marrow-derived cells. This review explores the role of circulating osteo-progenitor cells in vascular calcification pathogenesis.

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Area of Science:

Cardiovascular Research
Cell Biology
Vascular Biology

Background:

Vascular calcification is linked to cardiovascular events.
Historically viewed as passive, it's now understood as an active, cell-mediated process.
The cellular origins of vascular calcification are debated, with vascular smooth muscle cells and bone marrow-derived cells implicated.

Purpose of the Study:

To review the evidence for circulating osteo-progenitor cells contributing to vascular calcification.
To explore the role of bone marrow-derived cells in the pathogenesis of vascular calcification.

Main Methods:

Literature review of studies on vascular calcification and bone marrow-derived cells.
Analysis of research identifying circulating osteo-progenitor cells with osteogenic potential.

Main Results:

Vascular calcification pathogenesis is complex, involving active cellular processes.
A subset of immature bone marrow cells, termed osteo-progenitors, exhibit in vitro bone-forming properties.
Evidence suggests these circulating osteo-progenitor cells may play a role in vascular calcification.

Conclusions:

Circulating osteo-progenitor cells represent a novel source of cells involved in vascular calcification.
Understanding their contribution may offer new therapeutic targets for cardiovascular disease.