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Marantic endocarditis and adenocarcinoma of unknown primary site

Luis Alberto Schlittler1, Viviane Weiller Dallagasperina, Claudia Schavinski

  • 1Hospital da Cidade de Passo Fundo, RS, Brazil.

Arquivos Brasileiros De Cardiologia
|May 10, 2011
PubMed

Insights

Nonbacterial thrombotic endocarditis (NBTE) involves fibrin deposits on heart valves without bacteria. This case highlights NBTE in a patient with unknown adenocarcinoma, presenting with systemic embolism.

Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Nonbacterial thrombotic endocarditis (NBTE) is a non-infectious valvular disease.
  • NBTE is associated with chronic inflammatory conditions and malignancy.
  • It carries a higher risk of thromboembolic events compared to infective endocarditis.

Observation:

  • A 63-year-old male presented with systemic embolism.
  • The patient had adenocarcinoma of an unknown primary site.
  • Cardiac valve examination revealed nonbacterial thrombotic endocarditis.

Findings:

  • The case demonstrates a link between NBTE and advanced malignancy.
  • Systemic embolism was a presenting manifestation of NBTE in this patient.
  • The absence of microorganisms confirmed the non-infectious etiology.

Implications:

  • NBTE should be considered in patients with malignancy and embolic events.
  • Early diagnosis and management of NBTE can prevent further thromboembolic complications.
  • This case underscores the importance of investigating embolic phenomena in cancer patients.

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