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Published on: August 11, 2023

Optimising the management of choroidal neovascularisation in Asian patients: consensus on treatment recommendations

A Koh1, T H Lim, K G Au Eong

  • 1Eye and Retina Surgeons, Camden Medical Centre, 1 Orchard Boulevard, Singapore 248649. ahckoh@yahoo.com

Singapore Medical Journal
|May 10, 2011
PubMed

Insights

Wet age-related macular degeneration (AMD) causes vision loss in Asian countries. Combination therapy using anti-vascular endothelial growth factors (VEGF) with photodynamic therapy (PDT) shows promise for treating choroidal neovascularisation (CNV).

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Retina

Background:

  • Age-related macular degeneration (AMD), particularly wet AMD or choroidal neovascularisation (CNV), is a leading cause of vision impairment in Asian populations.
  • Vascular endothelial growth factors (VEGF) are crucial in CNV development, making them a key therapeutic target.
  • Current treatments for neovascular AMD include photodynamic therapy (PDT), but combination therapies may offer improved outcomes.

Purpose of the Study:

  • To outline consensus points and recommended treatment algorithms for Asian patients with CNV.
  • To provide a structured, evidence-based management approach for CNV in the Asian population.

Main Methods:

  • Review of current knowledge and evidence regarding CNV treatments.
  • Development of consensus-based treatment algorithms by the Singapore Medical Retina Advisory Board.

Main Results:

  • Anti-VEGF therapy, alone or combined with PDT, has significantly improved outcomes for CNV.
  • Anti-VEGF therapy is a potential first-line treatment for specific types of myopic CNV and juxtafoveal/subfoveal CNV.

Conclusions:

  • Combination therapy targeting multiple pathways, such as anti-VEGF with PDT, may enhance visual outcomes and reduce treatment duration for CNV.
  • Implementing evidence-based medicine is crucial for advancing patient care in managing CNV.

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