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The interaction between protein-kinase-C (pkc) and estrogens (review)
1GERMAN CANC RES CTR,NEUENHEIMER FELD 280,D-69120 HEIDELBERG,GERMANY.
International Journal of Oncology
|May 10, 2011
Summary
Estradiol influences protein kinase C (PKC) levels and activity. PKC activation decreases estrogen receptor (ER) levels, suggesting a link between PKC signaling and ER function in hormone-responsive tissues.
Area of Science:
- Endocrinology
- Molecular Biology
- Cell Signaling
Background:
- Protein kinase C (PKC) is a family of enzymes involved in cell signaling.
- Estradiol (ER) is a key steroid hormone regulating various physiological processes.
- Interactions between PKC and ER are implicated in hormone-dependent tissues.
Purpose of the Study:
- To review the interactions between protein kinase C (PKC) and estradiol (ER).
- To explore the regulatory effects of estradiol on PKC and vice versa.
- To understand the implications for hormone-responsive cells, including cancer.
Main Methods:
- Literature review of studies investigating PKC and ER interactions.
- Analysis of in vitro and in vivo experimental data.
- Examination of cellular and molecular changes in response to estradiol and PKC modulation.
Main Results:
- Estradiol upregulates PKC in the ovary, anterior pituitary, and mammary tissues.
- Tamoxifen, an antiestrogen, inhibits PKC activity.
- PKC activation decreases ER protein and mRNA levels in breast cancer cells.
- PKC inhibition or downregulation enhances ER binding.
Conclusions:
- There are significant links between the PKC signal transduction pathway and the estrogen receptor (ER) family.
- PKC plays a regulatory role in modulating ER levels and activity.
- Further research is needed to elucidate the specific roles of PKC isoforms in estradiol-influenced normal and cancerous tissues.
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