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Modulation of Cisplatin toxicity by glutathione
1NCI,RADIAT BIOL BRANCH,BETHESDA,MD 20892. NCI,SURG BRANCH,BETHESDA,MD 20892. THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT DERMATOL,PHILADELPHIA,PA 19107.
International Journal of Oncology
|May 10, 2011
Summary
Glutathione (GSH) protects against lethal chemotherapy toxicity. GSH administration reduced organ damage and increased survival rates when combined with cisplatin, suggesting potential for enhanced cancer treatment.
Area of Science:
- Oncology
- Pharmacology
- Toxicology
Background:
- Organ toxicity limits chemotherapy efficacy.
- Glutathione (GSH), a cellular thiol, aids in drug detoxification.
- Previous studies indicated GSH protects against cisplatin toxicity.
Purpose of the Study:
- To evaluate GSH's protective effects against cisplatin-induced toxicity.
- To determine if GSH impacts chemotherapeutic cure rates or tumor growth.
Main Methods:
- Animal models received cisplatin with or without GSH.
- Survival rates and indicators of renal toxicity were assessed.
- Tumor cure rates and size were compared between groups.
Main Results:
- GSH administration significantly increased survival post-cisplatin (90% vs. 35%).
- Concurrent GSH markedly reduced cisplatin-induced renal toxicity.
- No significant difference in tumor cure rates was observed; a slight increase in tumor size was noted with GSH.
Conclusions:
- GSH demonstrates significant protective effects against cisplatin's lethal and organ toxicities.
- GSH may protect both normal and malignant tissues.
- Further research is needed to optimize GSH dosing for clinical application.
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