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The expression of stat91, ras-independent signal transducer and activator, in human gastric carcinomas

K Kitahara1, W Yasui, H Kuniyasu

  • 1HIROSHIMA UNIV,SCH MED,DEPT PATHOL 1,MINAMI KU,HIROSHIMA 734,JAPAN. SAGA MED SCH,DEPT SURG,SAGA 849,JAPAN.

International Journal of Oncology
|May 10, 2011
PubMed

Insights

Signal transducer and activator of transcription (Stat91) protein is overexpressed in most gastric cancers. This overexpression may contribute to gastric cancer growth by mediating signals from growth factors and cytokines.

Area of Science:

  • Molecular biology
  • Oncology
  • Cell signaling

Background:

  • Interferon (IFN) and epidermal growth factor (EGF) activate cytoplasmic Stat91 protein via tyrosine phosphorylation.
  • Activated Stat91 translocates to the nucleus to regulate gene expression.

Purpose of the Study:

  • To investigate Stat91 mRNA and protein expression in gastric carcinoma cell lines and tissues.
  • To determine the correlation between Stat91 expression and gastric cancer development.

Main Methods:

  • Analysis of Stat91 mRNA and protein levels in 8 gastric carcinoma cell lines.
  • Examination of Stat91 mRNA and protein expression in 21 gastric carcinoma tissues and adjacent normal mucosa.

Main Results:

  • All 8 gastric carcinoma cell lines expressed Stat91 mRNA and protein.
  • 14 out of 21 (66%) gastric tumors showed higher Stat91 mRNA levels than normal mucosa.
  • 6 out of 8 (75%) tumor tissues exhibited higher Stat91 protein levels compared to normal gastric mucosa.

Conclusions:

  • The majority of gastric cancers exhibit Stat91 overexpression.
  • Stat91 may play a role in gastric cancer growth by transducing signals from cytokines and growth factors.
  • No significant correlation was found between Stat91 expression and clinicopathological features of gastric carcinoma.

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