Related Experiment Video
Updated: Jun 2, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
Published on: June 9, 2023
Pyrimidine nucleoside phosphorylase-activity and biological characteristics of breast-cancer
H Takahashi1, J Uchino, M Ogita
1OTARU MUNICIPAL HOSP,OTARU,HOKKAIDO,JAPAN. KONAN HOSP,SAPPORO,HOKKAIDO,JAPAN. NATL NISHI SAPPORO HOSP,HOKKAIDO CANC CTR,SAPPORO,HOKKAIDO,JAPAN. SAPPORO MUNICIPAL HOSP,SAPPORO,HOKKAIDO,JAPAN. TENSHI HOSP,FRANCISCAN MISSIONARIES MARY,SAPPORO,HOKKAIDO,JAPAN.
Abstract:
We investigated whether Pyrimidine nucleoside phosphorylase (PyNPase) activity in breast cancer tissue correlated with biological characteristics of breast cancer. PyNPase activity, ER, PgR, EGFR, DNA ploidy pattern, PCNA positive cells and amplification of the c-erbB-2 gene were determined in specimens from 138 patients. PyNPase activity was significantly higher in ER negative than ER positive carcinomas (p<0.05), in PgR negative than PgR positive carcinomas (p<0.05) and significantly higher in tumors with c-erbB-2 gene amplification compared with tumors with no amplification (p<0.05). The results suggest that PyNPase activity in breast cancer tissue may be a new biological characteristic of breast cancer.
Related Concept Videos
Biosynthesis of Nucleic Acids
Inhibition of Cdk Activity
Inhibition of CDK Activity
The Nucleolus
Abnormal Proliferation
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
