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Updated: Jun 2, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
A phase-ii study testing a combination chemotherapy with epirubicin and vindesine as 2nd line treatment for patients
J Sculier1, G Bureau, J Thiriaux
1GRP MED ST REMI,REIMS,FRANCE. HOP CIVIL,CHARLEROI,BELGIUM. HOP AMBROISE PARE,MONS,BELGIUM. HOP HAYANGE,HAYANGE,FRANCE. CTR HOSP ROUBAIX,ROUBAIX,FRANCE. CTR HOSP A VESALE,MONTIGNIES TILLEUL,BELGIUM.
Abstract:
The European Lung Cancer Working Party conducted a phase II trial to determine the activity of a salvage regimen with high dose epirubicin (120 mg/m(2) on day 1) and vindesine (3 mg/m(2) on day 1) in patients with advanced non-small cell lung cancer failing to respond to first-line chemotherapy containing cisplatin and/or carboplatin. Courses were repeated every 3 weeks and evaluation of antitumoral response was performed after the 2 first courses. A total of 53 patients were registered, 4 were not eligible and 42 were evaluable for response. Two (5%) objective responses were documented. Although the regimen was very well tolerated, based oh the results it has to be considered inactive.
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