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Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Updated: Jun 2, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

P53 mutations in egyptian bladder-cancer.

M Weintraub¹, H Khaled, A Zekri

¹NCI,PEDIAT BRANCH,BETHESDA,MD 20892. NCI,BIOSTAT BRANCH,BETHESDA,MD 20892. NATL CANC INST,DEPT MED ONCOL,CAIRO,EGYPT. NATL CANC INST,DEPT BIOL,CAIRO,EGYPT. NATL CANC INST,DEPT PATHOL,CAIRO,EGYPT.

International Journal of Oncology

|May 10, 2011

Summary

This summary is machine-generated.

p53 gene mutations are common in Egyptian bladder cancer, particularly in advanced stages. Immunohistochemistry effectively detects these mutations, aiding in prognosis assessment for bilharzial bladder cancer.

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Area of Science:

Oncology
Molecular Biology
Parasitology

Background:

Bladder cancer is prevalent in Egypt, often linked to Schistosoma haematobium infection.
Bilharzial bladder cancer exhibits distinct characteristics compared to that in industrialized nations.
Molecular alterations in Egyptian bladder cancer remain understudied.

Purpose of the Study:

To investigate the status of the p53 gene in Egyptian bladder cancer.
To correlate p53 gene mutations with clinical and histopathological features.
To evaluate the utility of immunohistochemistry in detecting p53 mutations.

Main Methods:

Studied 25 Egyptian bladder cancer cases.
Utilized immunohistochemistry for p53 protein detection.
Employed SSCP/sequencing to identify p53 gene mutations.

Main Results:

p53 gene mutations detected in 40% (10/25) of tumor samples.
Mutations occurred in both squamous and transitional cell variants.
p53 mutations were associated with advanced disease stage.
Immunohistochemistry showed 70% sensitivity and 85% specificity for mutation detection.

Conclusions:

p53 gene mutations are frequent in Egyptian bladder cancer and may indicate advanced disease.
Immunohistochemistry is a reliable method for detecting p53 mutations in this context.
Further assessment of p53 mutations' prognostic value is warranted.