Kinesin I ATPase manipulates biohybrids formed from tubulin and carbon nanotubes
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Updated: Jun 2, 2026

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
Published on: January 26, 2019
Cerasela Zoica Dinu1, Shyam Sundhar Bale, Jonathan S Dordick
1Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Center for Biotechnology and Interdisciplinary Studies, Troy, NY, USA. cerasela-zoica.dinu@mail.wvu.edu
Abstract:
This chapter describes a method for the formation of novel protein-nanotube hybrid conjugates. Specifically, we took advantage of the self-assembly and self-recognition properties of tubulin cytoskeletal protein immobilized onto carbon nanotubes to form nanotube-based biohybrids. Further biohybrid hierarchical integration in assemblies enabled molecular-level manipulation on engineered surfaces, as demonstrated with biocatalyst kinesin 1 ATPase molecular motor. The method presented herein can be extended for the preparation of biocatalyst-based or protein-based assemblies to be used as sensors or biological templates for nanofabrication.
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