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Structure and activity of hydrogenated derivatives of
T A Lyle1, C A Magill, S F Britcher
1Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania 19486.
Journal of Medicinal Chemistry
|March 1, 1990
Abstract:
Several hydrogenated derivatives of the potent NMDA antagonist 1 have been prepared and evaluated as competitive inhibitors of [3H]-1 binding. These compounds were also tested for their ability to act as noncompetitive antagonists of NMDA in vitro. These studies indicate that two aromatic rings are not strictly required for high-affinity binding or NMDA antagonism.