Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

Behavioural pharmacology·2002

In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone.

Circulation·2001

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

Journal of medicinal chemistry·2001

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro.

Neuropharmacology·2001

A comparison of the behavioural effects of 5-HT2A and 5-HT2C receptor agonists in the pigeon.

Behavioural pharmacology·2000

The effect of streptozotocin-induced diabetes on cell proliferation in the rat dentate gyrus.

Neuroscience letters·2000

Discovery of Monoterpenoid Indole Alkaloids Targeting CCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury.

Journal of medicinal chemistry·2026

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids.

Journal of medicinal chemistry·2026

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody-Oligonucleotide Conjugates with High Drug-to-Antibody Ratios.

Journal of medicinal chemistry·2026

Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.

Journal of medicinal chemistry·2026

Discovery, Synthesis, and Biological Evaluation of 1,3,4,5-Tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one Derivatives as Novel and Highly Selective PARP1 Inhibitors.

Journal of medicinal chemistry·2026

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.

Journal of medicinal chemistry·2026

Paralemnanoids A-K, new norsesquiterpenoids and sesquiterpenoids with hepatoprotective activity from the soft coral Paralemnalia sp.

Marine life science & technology·2026

Novel prenylated diketopiperazines with anti-osteoclastogenic activity from the deep-sea-derived Penicillium limosum ZEN48.

Marine life science & technology·2026

Polyphenols at the Helm: Excited State Photophysics and Mechanistic Insights Into Protein-Aggregation Inhibition Through Ultrafast Studies.

Chemistry, an Asian journal·2026

D2AAK1 derivatives as neuroprotective agents: Synthesis and structural and pharmacological evaluation.

Bioorganic chemistry·2026

"Synergistic Effect of CQDs on the Spectroscopic Behaviour and Bioactivity of Azo Dyes: Bio-imaging Applications".

Journal of fluorescence·2026

Evaluation of radical scavenging and antibacterial potency of leaf extracts from indigenous species of Cinnamomum tamala and Ocimum sanctum.

Biotechnology letters·2026

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Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

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m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

In vivo myocardial protection from ischemia/reperfusion injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone.

Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro.

A comparison of the behavioural effects of 5-HT2A and 5-HT2C receptor agonists in the pigeon.

The effect of streptozotocin-induced diabetes on cell proliferation in the rat dentate gyrus.

Discovery of Monoterpenoid Indole Alkaloids Targeting CCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury.

Selective Macrocyclic WEE1 Kinase Inhibitors with Strong Efficacy against Patient-Derived Colorectal Cancer Organoids.

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody-Oligonucleotide Conjugates with High Drug-to-Antibody Ratios.

Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.

Discovery, Synthesis, and Biological Evaluation of 1,3,4,5-Tetrahydro-6H-pyrano[4,3-c]isoquinolin-6-one Derivatives as Novel and Highly Selective PARP1 Inhibitors.

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.

Paralemnanoids A-K, new norsesquiterpenoids and sesquiterpenoids with hepatoprotective activity from the soft coral Paralemnalia sp.

Novel prenylated diketopiperazines with anti-osteoclastogenic activity from the deep-sea-derived Penicillium limosum ZEN48.

Polyphenols at the Helm: Excited State Photophysics and Mechanistic Insights Into Protein-Aggregation Inhibition Through Ultrafast Studies.

D2AAK1 derivatives as neuroprotective agents: Synthesis and structural and pharmacological evaluation.

"Synergistic Effect of CQDs on the Spectroscopic Behaviour and Bioactivity of Azo Dyes: Bio-imaging Applications".

Evaluation of radical scavenging and antibacterial potency of leaf extracts from indigenous species of Cinnamomum tamala and Ocimum sanctum.

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Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

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