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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
Published on: October 3, 2010
Atypical adult medulloblastoma
Maziar Behbahani1, Edward Jerome St George, Laurance T Dunn
1Department of Neurosurgery, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK. mbehbahani@me.com
Acta Neurochirurgica
|May 10, 2011
Summary
Adult medulloblastomas can mimic L'hermitte-Duclos disease, presenting with prolonged courses. Consider medulloblastoma in adults with posterior fossa masses, even if imaging suggests a low-grade tumor.
Area of Science:
- Neuro-oncology
- Pediatric and Adult Neoplasms
Background:
- Medulloblastomas are malignant primitive neuro-ectodermal tumors typically diagnosed in childhood.
- Adult medulloblastomas may exhibit distinct clinical, imaging, and prognostic features compared to pediatric cases.
Observation:
- This report details three adult patients with medulloblastoma.
- These patients presented with prolonged clinical courses and imaging findings resembling L'hermitte-Duclos disease.
Findings:
- Medulloblastoma should be included in the differential diagnosis for adult patients with posterior fossa masses.
- Clinical and radiological features suggestive of low-grade tumors do not exclude medulloblastoma in adults.
Implications:
- Histological confirmation is essential for the definitive diagnosis of adult medulloblastoma.
- Awareness of atypical presentations is crucial for timely diagnosis and management of medulloblastoma in adults.
