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Updated: Jun 2, 2026

Electroantennographic Bioassay as a Screening Tool for Host Plant Volatiles
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Electroantennographic Bioassay as a Screening Tool for Host Plant Volatiles

Published on: May 6, 2012

Modern screening techniques for plant extracts.

K Hostettmann1, J L Wolfender, C Terreaux

  • 1Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, Lausanne, Switzerland.

Pharmaceutical Biology
|May 11, 2011
PubMed
Summary
This summary is machine-generated.

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Discovering new plant-derived drugs requires simultaneous chemical screening and biological evaluation. This approach efficiently identifies novel bioactive compounds by distinguishing known from new molecules, avoiding tedious isolation.

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Drug Discovery

Background:

  • Plant-derived compounds are crucial sources for new drug leads.
  • Efficient methods are needed to screen plant extracts for bioactive molecules.
  • Dereplication of known compounds saves resources in drug discovery.

Purpose of the Study:

  • To outline a strategy for discovering novel bioactive compounds from tropical plants.
  • To emphasize the importance of integrating chemical and biological screening.
  • To illustrate the application of this approach in identifying molluscicidal, antioxidant, and antifungal agents.

Main Methods:

  • Simultaneous chemical screening using hyphenated techniques like LC/UV, LC/MS, and LC/NMR.
  • Biological evaluation using simple, reproducible, and rapid bioassays.

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Last Updated: Jun 2, 2026

Electroantennographic Bioassay as a Screening Tool for Host Plant Volatiles
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Screening for Phytoestrogens using a Cell-based Estrogen Receptor &#946; Reporter Assay
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Thin-layer Chromatographic (TLC) Separations and Bioassays of Plant Extracts to Identify Antimicrobial Compounds
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Thin-layer Chromatographic (TLC) Separations and Bioassays of Plant Extracts to Identify Antimicrobial Compounds

Published on: March 27, 2014

  • Utilizing spectroscopic data for direct compound identification and dereplication from crude extracts.

    • Main Results:

    • Hyphenated techniques rapidly provide structural information for compound identification.
    • Dereplication allows researchers to bypass isolation of known compounds.
    • Targeted isolation focuses on novel or unusual constituents.

    Conclusions:

    • Integrating chemical and biological screening accelerates the discovery of new bioactive compounds from plants.
    • This dual approach enhances efficiency by enabling direct identification and dereplication.
    • The strategy is effective for identifying diverse bioactive agents, such as molluscicidal, antioxidant, and antifungal compounds.