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Polymorphisms in NRAMP1 and MBL2 genes and their relations with tuberculosis in Turkish children

Hüseyin Avni Solğun1, Deniz Taştemir, Necmi Aksaray

  • 1Department of Pediatrics, Faculty of Medicine, Cukurova University, Adana, Turkey. hsynavn@gmail.com

Tuberkuloz Ve Toraks
|May 11, 2011
PubMed

Insights

Genetic analysis of NRAMP1 and MBL genes in children with tuberculosis revealed no significant association. These findings suggest these specific gene polymorphisms do not influence pediatric tuberculosis susceptibility.

Area of Science:

  • Genetics
  • Pediatrics
  • Infectious Diseases

Background:

  • Genetic factors play a role in tuberculosis susceptibility.
  • The NRAMP1 and MBL genes are potential candidates for influencing tuberculosis risk.

Purpose of the Study:

  • To investigate the association between NRAMP1 and MBL gene polymorphisms and genetic susceptibility to pediatric tuberculosis.
  • To compare gene frequencies in children with tuberculosis against a healthy control group.

Main Methods:

  • Analysis of NRAMP1 (D543N, 3'-UTR, INT4) and MBL (codon 54, 57) gene polymorphisms.
  • Study included 50 pediatric tuberculosis cases and 50 healthy controls aged 0-18 years.
  • Microsatellite analysis was performed on collected samples.

Main Results:

  • No significant association was found between NRAMP1 gene polymorphisms (INT4, G543A, 3-UTR) and tuberculosis in children (p>0.005).
  • No significant differences in MBL gene polymorphisms (codon 54, 57) were observed between tuberculosis patients and controls (p>0.05).

Conclusions:

  • NRAMP1 and MBL gene polymorphisms studied do not appear to be associated with susceptibility to pediatric tuberculosis.
  • Further research may be needed to explore other genetic factors contributing to tuberculosis heterogeneity.

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