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Updated: Jun 2, 2026

Infinium Assay for Large-scale SNP Genotyping Applications
Published on: November 19, 2013
Mapping of fertility traits in Finnish Ayrshire by genome-wide association analysis
N F Schulman1, G Sahana, T Iso-Touru
1MTT, Agrifood Research Finland, Biotechnology and Food Research, FIN-31600 Jokioinen, Finland. nina.schulman@mtt.fi
Abstract:
A whole-genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de-regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high-quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed-model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome-wide significant associations on eight different chromosomes. With at least chromosome-wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.
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