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Updated: Jun 2, 2026

ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography
Published on: August 25, 2023
Function and regulation of ABCA1--membrane meso-domain organization and reorganization
Kohjiro Nagao1, Maiko Tomioka, Kazumitsu Ueda
1Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan.
Abstract:
The ATP-binding cassette protein A1 (ABCA1) mediates the secretion of cellular-free cholesterol and phospholipids to an extracellular acceptor, apolipoprotein A-I, to form high-density lipoprotein. Because ABCA1 is a key factor in cholesterol homeostasis, elaborate transcriptional and post-transcriptional regulations of ABCA1 have evolved to maintain cholesterol homeostasis. Recent studies suggest that ABCA1 moves lipids not only between membranes but also within membranes to organize and reorganize membrane meso-domains to modulate cell proliferation and immunity.
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