Central Somatostatin Inhibits Cholecystokinin-lnduced Oxytocin Secretion in Conscious Rats
R E Blackburn1, S E Frederick, E M Strieker
1Departments of Medicine and Behavioral Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Journal of Neuroendocrinology
|May 11, 2011
Summary
Somatostatin-28 (SS-28) inhibits oxytocin (OT) release stimulated by cholecystokinin in rats. Central SS-28 also increases food intake, suggesting a role in ingestive behaviors.
Area of Science:
- Neuroendocrinology
- Neuropeptide signaling
Background:
- Brainstem somatostatin-28 (SS-28) fibers innervate oxytocin (OT) cells in the supraoptic nucleus.
- The physiological role of this SS-28 pathway in neurohypophysial hormone secretion is not fully understood.
Purpose of the Study:
- To investigate the inhibitory role of SS-28 on cholecystokinin-stimulated oxytocin release.
- To explore the effect of central SS-28 administration on food intake in rats.
Main Methods:
- Rats received intracerebroventricular injections of SS-28 or artificial cerebrospinal fluid.
- Plasma OT levels were measured after intraperitoneal cholecystokinin or hypertonic saline administration.
- Food intake was quantified in sated rats following central SS-28 administration.
Main Results:
- Cholecystokinin-induced OT release was significantly blunted by central SS-28 pretreatment.
- SS-28 did not affect basal OT levels or OT release induced by hypertonic saline.
- Central SS-28 administration increased food intake in sated rats.
Conclusions:
- Central SS-28 selectively inhibits cholecystokinin-stimulated OT release, supporting an inhibitory role in neurohypophysial hormone secretion.
- Endogenous SS-28 may stimulate food intake, suggesting a role in ingestive behavior regulation.
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