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Published on: August 9, 2012

The efficacy of oral midazolam for decreasing anxiety in children undergoing voiding cystourethrogram: a randomized,

Genoa G Ferguson1, Cathy Chen, Yan Yan

  • 1Division of Urology, Washington University School of Medicine, St. Louis, Missouri, USA.

The Journal of Urology
|May 11, 2011
PubMed

Insights

Oral midazolam did not significantly reduce anxiety in children undergoing voiding cystourethrogram (VCUG). The study found no significant benefits for child anxiety, parent anxiety, or post-procedure behavior.

Area of Science:

  • Pediatric Radiology
  • Pediatric Anesthesiology
  • Child Psychology

Background:

  • Voiding cystourethrogram (VCUG) is an essential diagnostic imaging procedure for pediatric urinary tract infections.
  • The invasive nature of VCUG can induce significant anxiety in children and their parents.
  • Effective anxiety management strategies are crucial for improving the patient experience during VCUG.

Purpose of the Study:

  • To evaluate the efficacy of oral midazolam in reducing pre-procedural anxiety in children undergoing VCUG.
  • To assess the impact of midazolam on parent anxiety levels during the procedure.
  • To investigate the effect of midazolam on post-procedural behavioral outcomes and healthcare provider perceptions.

Main Methods:

  • A double-blind, randomized controlled trial involving 44 children undergoing VCUG.
  • Children were randomized to receive either oral midazolam or a placebo prior to the procedure.
  • Anxiety was measured using the Modified Yale Preoperative Anxiety Scale (children) and State-Trait Anxiety Inventory (parents). Post-procedure behavior was assessed using the Post Hospitalization Behavior Questionnaire.

Main Results:

  • No statistically significant difference in anxiety scores was observed between the midazolam and placebo groups for children.
  • Parental anxiety levels during the VCUG were also not significantly different between the two groups.
  • Radiology staff perceived no reliable benefit of midazolam, and no adverse behavioral outcomes were noted in children up to six months post-procedure.

Conclusions:

  • Oral midazolam does not appear to significantly alleviate anxiety in children undergoing voiding cystourethrogram.
  • The medication showed no significant benefit in reducing parental anxiety or improving post-procedural behavior in children.
  • Healthcare provider perceptions suggest midazolam offers no reliable advantage for anxiety reduction during VCUG procedures.
Abstract

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