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Updated: Jun 2, 2026
12:55
Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells
Published on: October 10, 2017
The many faces of tau.
Meaghan Morris1, Sumihiro Maeda, Keith Vossel
1Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
Neuron
|May 11, 2011
Summary
The protein tau, known for microtubule binding, also plays new roles in cell signaling and organization. This review explores these functions and tau
Area of Science:
- Neuroscience
- Cell Biology
- Biochemistry
Background:
- The protein tau is traditionally recognized for its role in binding microtubules.
- Emerging research reveals novel functions of tau beyond microtubule stabilization.
Purpose of the Study:
- To review the newly identified functions of tau in cellular signaling and organization.
- To discuss the implications of these tau functions in neurodegenerative diseases.
- To explore therapeutic strategies targeting tau biology.
Main Methods:
- Literature review of recent studies on tau protein.
- Analysis of tau's involvement in signaling pathways.
- Evaluation of tau's role in cytoskeletal dynamics.
Main Results:
- Tau participates in crucial cellular signaling pathways.
- Tau influences cytoskeletal organization, impacting cell structure and function.
- Dysregulation of these tau functions is implicated in neurodegenerative conditions.
Conclusions:
- Tau is a multifunctional protein with significant roles in neuronal health.
- Understanding novel tau functions is critical for deciphering neurodegenerative disease mechanisms.
- Targeting tau offers promising therapeutic avenues for treating these debilitating diseases.
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