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Updated: Jun 2, 2026
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
Published on: March 24, 2023
The application of natural orifice surgery for adenocarcinoma of the prostate
Brian Duty1, Ornob Roy, Salvatore Micali
1Arthur Smith Institute for Urology, North Shore-Long Island Jewish Health System, New Hyde Park, NY 06883, USA. bduty@nshs.edu
Abstract:
Prostate cancer remains the most common solid organ malignancy in men. Unfortunately, surgical management of this disease is often associated with significant morbidity. In an effort to decrease the invasiveness and deleterious impact on quality of life associated with prostate cancer surgery, minimally invasive techniques have been applied to this disease. At present, the robotic-assisted laparoscopic radical prostatectomy has become the most commonly performed surgical treatment modality for adenocarcinoma of the prostate. Recently, several centers within the United States have begun to evaluate the feasibility of applying natural orifice translumenal endoscopic surgery to prostate cancer. This review article details the initial work done on cadaveric and canine models to develop the transurethral radical prostatectomy procedure. Potential advantages and disadvantages of this modality, as well as challenges facing its continued development, are highlighted.
Insights
Minimally invasive prostate cancer surgery is evolving. Transurethral radical prostatectomy, a new natural orifice endoscopic technique, is being developed to reduce surgical morbidity and improve patient quality of life.
Area of Science:
- Urology
- Surgical Oncology
- Minimally Invasive Surgery
Background:
- Prostate cancer is the most common male malignancy.
- Current surgical treatments often cause significant morbidity and impact quality of life.
- Minimally invasive techniques aim to reduce these negative effects.
Purpose of the Study:
- To review the development of transurethral radical prostatectomy (TURP) for prostate cancer.
- To explore the feasibility of natural orifice translumenal endoscopic surgery (NOTES) for prostatectomy.
- To highlight the potential benefits and challenges of this novel approach.
Main Methods:
- Review of initial research on cadaveric and canine models.
- Exploration of transurethral endoscopic techniques for prostatectomy.
- Analysis of potential advantages and disadvantages of the transurethral approach.
Main Results:
- Initial work in cadaveric and canine models has demonstrated the feasibility of the transurethral radical prostatectomy procedure.
- Robotic-assisted laparoscopic radical prostatectomy is currently the most common surgical treatment.
- Natural orifice translumenal endoscopic surgery is being evaluated for prostate cancer treatment.
Conclusions:
- Transurethral radical prostatectomy represents a potential advancement in minimally invasive prostate cancer surgery.
- Further development is needed to overcome challenges and establish its clinical utility.
- This technique may offer advantages in reducing morbidity and improving patient outcomes.
