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Updated: Jun 2, 2026

A Droplet-Based Microfluidic Approach and Microsphere-PCR Amplification for Single-Stranded DNA Amplicons
Published on: November 14, 2018
Novel molecularly imprinted microsphere using a single chiral monomer and chirality-matching (S)-ketoprofen template
Jiabing Jiang1, Kesheng Song, Zhi Chen
1Department of Chemistry, South China Normal University, Guangzhou 510006, China.
Abstract:
We designed and synthesized a cinchonine derivative to be used as a novel chiral monomer. It was employed in a dual role of functional monomer and cross-linking monomer, displaying multi-binding sites for the template (S)-ketoprofen. Monodisperse molecularly imprinted core-shell microspheres were prepared using surface imprinting method on silica gel. The results show a substantial synergistic effect in the enantioselective recognition, confirming our initial hypothesis. Computational simulation of the monomer and template pre-arrangement strongly supports our proposed chiral recognition mechanism for the imprinted microspheres.
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