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Related Experiment Video

Updated: Jun 2, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

Advanced life support versus basic life support in the pre-hospital setting: a meta-analysis.

G Bakalos¹, M Mamali, C Komninos

¹University of Athens School of Medicine, Post Graduate Program on International Medicine, Health Crisis Management, Athens, Greece. bakalosg@otenet.gr

|May 11, 2011

Summary

Advanced life support (ALS) improves survival for cardiac arrest patients but not for trauma patients in pre-hospital settings. Further research is unlikely to alter these findings for cardiac arrest survivors.

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Area of Science:

Emergency medicine
Pre-hospital care
Clinical effectiveness research

Background:

Limited evidence exists on the benefits of Advanced Life Support (ALS) in pre-hospital trauma or acute illness care.
Existing research often lacks controlled studies to definitively assess ALS impact on survival.

Purpose of the Study:

To systematically review controlled studies evaluating if pre-hospital Advanced Life Support (ALS) improves patient survival compared to Basic Life Support (BLS).
To identify specific patient groups that benefit from ALS interventions in pre-hospital settings.

Main Methods:

A systematic review of controlled studies was conducted, searching databases like Medline, EMBASE, Cochrane Library, and Scopus up to July 31st, 2010.
Studies comparing pre-hospital ALS treatment versus BLS treatment in trauma patients or cardiac arrest patients were included.

Main Results:

ALS care did not increase survival in 16,857 trauma patients compared to BLS (pooled OR 0.892).
ALS care significantly increased survival in 7,659 cardiac arrest patients compared to BLS (OR 1.468).
Physician-led ALS interventions further enhanced survival probability in cardiac arrest patients (OR 2.047).

Conclusions:

Implementing ALS for non-traumatic cardiac arrest patients demonstrably increases survival rates.
ALS care is not associated with improved survival in trauma patients based on current meta-analysis.
The scarcity of high-quality controlled studies on pre-hospital ALS for trauma patients limits definitive conclusions.