Related Experiment Video
Updated: Jun 2, 2026
A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence
Published on: May 26, 2023
Fundus autofluorescence in autosomal dominant occult macular dystrophy
Kaoru Fujinami1, Kazushige Tsunoda, Gen Hanazono
1Laboratory of Visual Physiology, National Institute of Sensory Organs, 2-5-1, Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.
Objective:
To characterize fundus autofluorescence (FAF) images of eyes with autosomal dominant occult macular dystrophy (OMD).
Methods:
All patients received a comprehensive ophthalmologic examination for diagnosis of OMD. We evaluated the FAF images in 13 eyes of 7 patients with autosomal dominant OMD by confocal scanning laser ophthalmoscopy with excitation at 488 nm and emission more than 500 nm.
Results:
The FAF images showed unspecific weak foveal hyperfluorescence in 4 eyes of 2 patients; one showed a thin hyperfluorescence in the temporal fovea bilaterally and the other showed weak hyperfluorescence in the fovea bilaterally. The optical coherence tomographic images showed abnormalities of the photoreceptor inner segment-outer segment line and cone outer segment tip line in all patients. However, 5 patients had normal FAF images regardless of morphological abnormalities of the photoreceptor.
Conclusions:
Fundus autofluorescence is a useful method to acquire additional information of photoreceptor/retinal pigment epithelium function in eyes with OMD. Fundus autofluorescence will be also helpful for the differential diagnosis of eyes with OMD vs eyes with other dystrophies that have a distinctive FAF pattern.
